Cann S A, van Netten J P, van Netten C
Special Development Laboratory, Royal Jubilee Hospital, Victoria, BC, Canada.
Cancer Causes Control. 2000 Feb;11(2):121-7. doi: 10.1023/a:1008925301459.
In this paper we examine some of the evidence linking iodine and selenium to breast cancer development. Seaweed is a popular dietary component in Japan and a rich source of both of these essential elements. We hypothesize that this dietary preference may be associated with the low incidence of benign and malignant breast disease in Japanese women. In animal and human studies, iodine administration has been shown to cause regression of both iodine-deficient goiter and benign pathological breast tissue. Iodine, in addition to its incorporation into thyroid hormones, is organified into anti-proliferative iodolipids in the thyroid; such compounds may also play a role in the proliferative control of extrathyroidal tissues. Selenium acts synergistically with iodine. All three mono-deiodinase enzymes are selenium-dependent and are involved in thyroid hormone regulation. In this way selenium status may affect both thyroid hormone homeostasis and iodine availability.
Although there is suggestive evidence for a preventive role for iodine and selenium in breast cancer, rigorous retrospective and prospective studies are needed to confirm this hypothesis.
在本文中，我们研究了一些将碘和硒与乳腺癌发生联系起来的证据。海藻是日本流行的饮食成分，也是这两种必需元素的丰富来源。我们推测，这种饮食偏好可能与日本女性良性和恶性乳腺疾病的低发病率有关。在动物和人体研究中，已表明给予碘可使碘缺乏性甲状腺肿和良性病理性乳腺组织消退。碘除了被纳入甲状腺激素外，还在甲状腺中被有机化为抗增殖碘脂质；此类化合物也可能在甲状腺外组织的增殖控制中发挥作用。硒与碘协同作用。所有三种单脱碘酶均依赖硒，且参与甲状腺激素调节。通过这种方式，硒状态可能会影响甲状腺激素稳态和碘的可用性。
尽管有提示性证据表明碘和硒在乳腺癌中具有预防作用，但仍需要严格的回顾性和前瞻性研究来证实这一假设。
