Miniero R, D'Archivio M, Olivieri A, De Angelis S, Sorcini M
Laboratorio di Alimenti, Istituto Superiore di Sanità, Roma.
Ann Ist Super Sanita. 1998;34(3):349-55.
Recent studies reported the role of several trace elements in health and disease. The role of iodine deficiency in thyroid dysfunction is well known. Also the selenium deficiency has been reported to be correlated to thyroid dysfunctions. In fact, although the major role of selenium is related to the glutathione peroxidase system, which protects cellular structures from oxidative damages, selenium plays also an important role in thyroid hormone metabolism as an essential component of the three deiodinase. These regulate inter-conversion of active and inactive forms of iodothyronines. Several studies have been carried out to establish the role of combined selenium and iodine deficiency. This review aims to provide information on the relationship between selenium and iodine intake and thyroid function. Furthermore, the state of art on the effects of the combined deficiency of selenium and iodine is also provided.
近期研究报道了几种微量元素在健康与疾病中的作用。碘缺乏在甲状腺功能障碍中的作用众所周知。此外，据报道硒缺乏与甲状腺功能障碍相关。事实上，尽管硒的主要作用与谷胱甘肽过氧化物酶系统有关，该系统可保护细胞结构免受氧化损伤，但硒作为三种脱碘酶的必需成分，在甲状腺激素代谢中也起着重要作用。这些酶调节碘甲状腺原氨酸活性和非活性形式的相互转化。已经开展了多项研究来确定硒和碘联合缺乏的作用。本综述旨在提供有关硒和碘摄入量与甲状腺功能之间关系的信息。此外，还介绍了硒和碘联合缺乏影响的最新研究状况。
