Shamelian S O, Nortier J W
Department of Internal Medicine, Carolus-Liduina Hospital, Hertogenbosch, The Netherlands.
Neth J Med. 2000 Feb;56(2):51-5. doi: 10.1016/s0300-2977(99)00122-9.
Three male patients with extrapulmonary small-cell carcinoma originating from esophagus, pancreas and prostate are described. The patient with the esophagus tumor had a combined small-cell and undifferentiated carcinoma. The other two patients had a pure small-cell carcinoma. All patients were treated with primary combination chemotherapy consisting of etoposide and cisplatin followed in one patient by locoregional radiotherapy. The patients with the esophagus and the pancreas tumor showed a partial response; the patient with the prostate tumor achieved a complete remission but relapsed with brain metastasis. All patients are alive 7, 13 and 19 months, respectively after initiation of the therapy. As in pulmonary small-cell carcinoma, primary chemotherapy is the treatment of choice in extrapulmonary small-cell carcinoma.
本文描述了3例分别起源于食管、胰腺和前列腺的肺外小细胞癌男性患者。食管肿瘤患者为小细胞癌与未分化癌混合存在。另外两名患者为单纯小细胞癌。所有患者均接受了以依托泊苷和顺铂为主的初始联合化疗，其中1例患者随后接受了局部区域放疗。食管和胰腺肿瘤患者显示部分缓解；前列腺肿瘤患者达到完全缓解，但出现脑转移复发。所有患者在开始治疗后分别存活了7个月、13个月和19个月。与肺小细胞癌一样，初始化疗是肺外小细胞癌的首选治疗方法。
