阑尾原发性混合性腺癌和小细胞癌：一例报告（符合 CARE 标准）
Primary mixed adenocarcinoma and small-cell carcinoma of appendix: A case report (CARE-compliant).
作者信息
Kim Woo Seok, Lee Dong Gi
机构信息
Department of Surgery.
Department of Anesthesiology and Pain Medicine, Soonchunhyang University Hospital Gumi, Gumi, Gyeongsangbuk-do, Republic of Korea.
出版信息
Medicine (Baltimore). 2019 May;98(19):e15614. doi: 10.1097/MD.0000000000015614.
RATIONALE
Primary extrapulmonary small-cell carcinoma (SCC) of appendix is reported very rarely. We report herein a case of mixed SCC and adenocarcinoma of appendix.
PATIENT'S CONCERN: A 70-year-old female was consulted to our Emergency Department with the right lower abdominal pain and low-grade fever for 2 days.
DIAGNOSIS
Abdominal ultrasonography revealed the perforated appendicitis with periappendiceal abscess. Postoperative histology confirmed the diagnosis of mixed SCC and adenocarcinoma.
INTERVENTIONS
After laparoscopic appendectomy, she underwent right hemicolectomy for radical surgery.
OUTCOMES
Laparoscopic appendectomy was performed and histological examination showed mixed SCC and adenocarcinoma. After confirming that there was no other organ metastasis, right hemicolectomy was performed for radical surgery. Five months after surgery, the patient expired due to multiple organ metastases.
LESSONS
Further studies are required for better understanding of disease entities, and clinical trials are needed to define adequate treatment strategies for extrapulmonary SCC.
理论依据
阑尾原发性肺外小细胞癌（SCC）的报道极为罕见。我们在此报告一例阑尾混合性SCC和腺癌病例。
患者情况
一名70岁女性因右下腹痛和低热2天前来我院急诊科就诊。
诊断
腹部超声显示阑尾穿孔伴阑尾周围脓肿。术后组织学检查确诊为混合性SCC和腺癌。
干预措施
在腹腔镜阑尾切除术后，她接受了右半结肠切除术以进行根治性手术。
结果
进行了腹腔镜阑尾切除术，组织学检查显示为混合性SCC和腺癌。在确认无其他器官转移后，进行了右半结肠切除术以进行根治性手术。术后五个月，患者因多器官转移死亡。
经验教训
需要进一步研究以更好地了解疾病实体，并且需要进行临床试验以确定肺外SCC的适当治疗策略。
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