Sander E E, Collard J G
Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Eur J Cancer. 1999 Dec;35(14):1905-11. doi: 10.1016/s0959-8049(99)00293-2.
The family members of small Rho-like GTPases, RhoA, Rac1 and Cdc42Hs, are regulators of diverse cellular signalling pathways, including cytoskeletal organisation, transcription and cell-cycle progression. Recent research has given insight into the complex regulation of cell-cell adhesion and migratory responses of epithelial cells. The Rho-like GTPases RhoA, Rac1 and Cdc42Hs as major determinants of cytoskeletal organisation have been identified as key regulators of epithelial architecture, as well as of cell migration. These findings highlight the complex regulation and cross-talk of GTPase-dependent signalling pathways arising from cell-cell and cell-matrix interactions. The molecular mechanism of how Rho-like GTPases couple to molecules mediating either cell-cell adhesion or cell migration will be of particular interest to understand the invasive phenotype of epithelial tumours.
小Rho样GTP酶家族成员RhoA、Rac1和Cdc42Hs是多种细胞信号通路的调节因子，包括细胞骨架组织、转录和细胞周期进程。最近的研究深入了解了上皮细胞间细胞黏附及迁移反应的复杂调节机制。Rho样GTP酶RhoA、Rac1和Cdc42Hs作为细胞骨架组织的主要决定因素，已被确定为上皮结构以及细胞迁移的关键调节因子。这些发现突出了由细胞间和细胞与基质相互作用产生的GTP酶依赖性信号通路的复杂调节和相互作用。Rho样GTP酶如何与介导细胞间黏附或细胞迁移的分子偶联的分子机制，对于理解上皮肿瘤的侵袭表型将具有特别重要的意义。
