Meschia M, Pansini F, Modena A B, de Aloysio D, Gambacciani M, Parazzini F, Campagnoli C, Maiocchi G, Peruzzi E
Department of Obstetrics and Gynaecology, Milano, Italy.
Maturitas. 2000 Feb 15;34(2):119-25. doi: 10.1016/s0378-5122(99)00095-x.
To identify the determinants of age at menopause in an Italian population, using data from the Italian Climacteric Research Group Study (ICARUS).
ICARUS is a prospective study of the effect of menopause on women's health that has been running in menopause clinics throughout Italy since 1995. A total of 4300 women with spontaneous menopause, aged 55 years or more and observed for the first time at the participating centres are included in the present analysis.
The mean age at menopause in the total population was 50.9 years. After taking into account potential covariates, the women reported smoking, had a slightly lower mean age at menopause than non smokers 50.4 versus 50.9 years; P = 0.01. The mean age at menopause in nulliparae was 50.0 years, and, respectively 50.4, 50.6, 50.9, 51.2 and 50.9 years in those reporting 1, 2, 3, 4 and 5 or more births (P < 0.01). A low body mass index and an early age at menarche were associated with early menopause in the crude analysis, but these associations disappeared after taking into account the confounding factors.
This study offers an estimate of the mean age at menopause of women attending menopause clinics in Italy, on the basis of the data obtained from a large sample. It also indicates that smoking and nulliparity are associated with early menopause.
利用意大利更年期研究组研究（ICARUS）的数据，确定意大利人群绝经年龄的决定因素。
ICARUS是一项关于更年期对女性健康影响的前瞻性研究，自1995年以来一直在意大利各地的更年期诊所开展。本分析纳入了4300名自然绝经、年龄在55岁及以上且首次在参与中心接受观察的女性。
总体人群的平均绝经年龄为50.9岁。在考虑潜在协变量后，报告吸烟的女性绝经平均年龄略低于不吸烟者，分别为50.4岁和50.9岁；P = 0.01。未生育女性的平均绝经年龄为50.0岁，报告生育1、2、3、4和5次或更多次的女性平均绝经年龄分别为50.4、50.6、50.9、51.2和50.9岁（P < 0.01）。在粗分析中，低体重指数和初潮年龄早与绝经早有关，但在考虑混杂因素后，这些关联消失。
本研究基于从大样本获得的数据，对意大利更年期诊所就诊女性的平均绝经年龄进行了估计。研究还表明，吸烟和未生育与绝经早有关。
