通过综合单变量、多变量和网络分析对健康受试者的血脂蛋白和脂质组分谱进行探索，揭示了脂肪酶活性和胆固醇酯化与性别和年龄的关联。

Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age.

作者信息

Balder Yasmijn, Vignoli Alessia, Tenori Leonardo, Luchinat Claudio, Saccenti Edoardo

机构信息

Laboratory of Systems and Synthetic Biology, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands.

Magnetic Resonance Center (CERM) and Department of Chemistry "Ugo Schiff", University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Italy.

出版信息

Metabolites. 2021 May 18;11(5):326. doi: 10.3390/metabo11050326.

In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong association of lipoprotein and lipid main fraction profiles with sex and age. Our results suggest an age-dependent remodulation of lipase lipoprotein activity in men and a change in the mechanisms controlling the ratio between esterified and non-esterified cholesterol in both men and women.