Zaia A, Piantanelli L
Gerontologic Research Department, Center of Biochemistry, INRCA, Ancona, Italy.
Mech Ageing Dev. 2000 Feb 15;113(3):227-32. doi: 10.1016/s0047-6374(99)00118-9.
The aim of the present study was to analyze whether aging also affects central insulin receptors in brain cortex as it does in whole brain of BALB/c-nu mice. Results showed statistically significant decrease of number and increase of affinity of insulin high affinity binding sites in old animals. As a consequence, central insulin actions, among which neuromodulation of monoaminergic system, can result altered during aging.
