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[衰老过程中大鼠肝脏胰岛素受体的下调]

[Down regulation of insulin receptors in the rat liver in aging].

作者信息

Gatsko G G, Linnik I V

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1987 Dec;73(12):1691-5.

PMID:3327708
Abstract

No decrease in the specific binding of 125I-insulin in the liver plasmatic membranes in response to insulin administration (2 units per 100 g/w) occurred in 24-26 month old rats whereas the response was obvious in 5-6 month old animals. The older animals showed a less obvious response of insulin receptors to 2-week administration of the hormone.

摘要

给24 - 26月龄大鼠注射胰岛素(每100克体重2单位)后,其肝质膜中125I - 胰岛素的特异性结合没有降低,而在5 - 6月龄动物中这种反应很明显。老龄动物对该激素进行为期2周的给药后,胰岛素受体的反应不太明显。

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