Connor J, Makonnen E, Rostom A
Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey 17033, USA.
J Pharm Pharmacol. 2000 Jan;52(1):107-10. doi: 10.1211/0022357001773580.
We have compared the analgesic properties of khat (Catha edulis Forsk) extract, amphetamine and ibuprofen in mice. After intragastric administration of the drugs analgesia was measured relative to water-injected controls using the hot-plate, the tail-flick, and abdominal-constriction tests. At the highest doses examined (amphetamine 1.8 mg kg(-1), ibuprofen 90 mg kg(-1), khat extract 1800 mg kg(-1)), all three substances produced analgesia, but the order of efficacy varied with the test. Khat and ibuprofen were significantly different from the control in the hot-plate assay at three or more time points post-injection. In the tail-flick test, khat and amphetamine were efficacious; ibuprofen means were somewhat lower but still significantly different from control. Higher doses of the drugs decreased the number of responses in the acetic acid-induced abdominal-constriction assay. We conclude that khat, like amphetamine and ibuprofen, can relieve pain. Differences in assay results may reflect differences in modes and sites of action, as well as in the type of pain generated by the chemical and thermal stimuli for nociception.
我们比较了巧茶（Catha edulis Forsk）提取物、苯丙胺和布洛芬在小鼠体内的镇痛特性。在给小鼠灌胃给药后，使用热板法、甩尾法和腹部收缩试验，相对于注射水的对照组来测量镇痛效果。在所检测的最高剂量下（苯丙胺1.8毫克/千克、布洛芬90毫克/千克、巧茶提取物1800毫克/千克），所有三种物质均产生了镇痛作用，但疗效顺序因试验而异。在热板试验中，注射后三个或更多时间点，巧茶和布洛芬与对照组有显著差异。在甩尾试验中，巧茶和苯丙胺有效；布洛芬的平均值略低，但仍与对照组有显著差异。更高剂量的药物减少了醋酸诱导的腹部收缩试验中的反应次数。我们得出结论，巧茶与苯丙胺和布洛芬一样，能够缓解疼痛。试验结果的差异可能反映了作用方式和作用部位的差异，以及化学和热刺激产生伤害性感受所引发的疼痛类型的差异。
