Makonnen E
Department of Pharmacology, Faculty of Medicine, Addis Ababa University.
Phytomedicine. 2000 Jul;7(4):309-12. doi: 10.1016/S0944-7113(00)80049-5.
The constipating and spasmolytic effects of Catha edulis Forsk (Khat) were investigated in whole mice and on isolated guinea pig ileum. D-amphetamine was employed in both experiments for comparison. The total distance travelled (expressed in percentage) by charcoal suspension in the gastrointestinal tract of mice was determined before and after khat administration. The procedure was repeated with amphetamine and normal saline. The results were compared. Amplitudes of contraction were recorded with standard spasmogens, histamine and carbachol, in the presence and absence of khat extract of different concentrations. The same was done with amphetamine. Khat extract was observed to reduce the total distance travelled by charcoal suspension, comparable to D-amphetamine. The spasmogenic effects of both histamine and carbachol were observed to be antagonized by the khat extract in a concentration-dependent manner. The antispasmodic effect of khat extract was observed to be similar to that of D-amphetamine.
在整体小鼠和离体豚鼠回肠上研究了巧茶（Catha edulis Forsk）的致便秘和抗痉挛作用。在两个实验中均使用右旋苯丙胺作为对照。在给予巧茶前后，测定小鼠胃肠道中炭末悬液移动的总距离（以百分比表示）。用苯丙胺和生理盐水重复该过程。比较结果。在存在和不存在不同浓度巧茶提取物的情况下，用标准致痉剂组胺和卡巴胆碱记录收缩幅度。对苯丙胺也进行同样操作。观察到巧茶提取物可减少炭末悬液移动的总距离，与右旋苯丙胺相当。观察到组胺和卡巴胆碱的致痉作用均被巧茶提取物以浓度依赖性方式拮抗。观察到巧茶提取物的解痉作用与右旋苯丙胺相似。
