Sarikaya A, Sen S, Cermik T F, Birtane M, Berkarda S
Department of Nuclear Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey.
Nucl Med Commun. 2000 Jan;21(1):83-7. doi: 10.1097/00006231-200001000-00014.
It is well known that uraemia affects skeletal muscle metabolism. This has been attributed to a variety of causes, including anaemia, vitamin D, carnitine deficiency and hyperparathyroidism. The aim of this study was to ascertain whether 99Tcm-sestamibi leg scintigraphy is useful in the evaluation of skeletal muscle metabolism and the monitoring of treatment response in uraemic myopathy. Forty patients with chronic renal failure and 24 normal controls underwent examination. Fifteen patients with chronic renal failure received erythropoietin treatment. 99Tcm-sestamibi leg scintigraphy was performed in all subjects and in 15 patients after therapy. The calf-to-ankle uptake ratio was calculated by semi-quantitative analysis and normalized to lean body mass. The normalized uptake ratios were significantly different between patients and controls. After erythropoietin therapy, there was a significant increase in the normalized uptake ratios compared with pre-therapy. Our results suggest that 99Tcm-sestamibi leg scintigraphy is useful in the assessment of muscle metabolic abnormalities and the effect of treatment in uraemic myopathy.
众所周知，尿毒症会影响骨骼肌代谢。这归因于多种原因，包括贫血、维生素D、肉碱缺乏和甲状旁腺功能亢进。本研究的目的是确定99锝-甲氧基异丁基异腈腿部闪烁扫描在评估尿毒症性肌病的骨骼肌代谢及监测治疗反应方面是否有用。40例慢性肾衰竭患者和24例正常对照者接受了检查。15例慢性肾衰竭患者接受了促红细胞生成素治疗。对所有受试者及15例治疗后的患者进行了99锝-甲氧基异丁基异腈腿部闪烁扫描。通过半定量分析计算小腿至脚踝的摄取率，并将其标准化为去脂体重。患者与对照者之间标准化摄取率存在显著差异。促红细胞生成素治疗后，与治疗前相比，标准化摄取率显著增加。我们的结果表明，99锝-甲氧基异丁基异腈腿部闪烁扫描在评估尿毒症性肌病的肌肉代谢异常及治疗效果方面是有用的。
