大鼠中脑导水管周围灰质内注射神经肽Y诱导的抗伤害感受作用。
Antinociceptive effects induced by intra-periaqueductal grey administration of neuropeptide Y in rats.
作者信息
Wang J Z, Lundeberg T, Yu L
机构信息
Department of Physiology, College of Life Science, Peking University, Beijing, China.
出版信息
Brain Res. 2000 Mar 24;859(2):361-3. doi: 10.1016/s0006-8993(99)02408-7.
Abstract
Hindpaw withdrawal latency (HWL) to thermal and mechanical stimulation increased dose-dependently after intra-periaqueductal grey (PAG) injection of neuropeptide Y (NPY). Furthermore, the NPY-induced increases in HWLs were attenuated by intra-PAG injection of the Y1 receptor antagonist NPY28-36. The results demonstrated that NPY plays an important role in antinociception in PAG, in which Y1 receptor is involved in.
摘要
在脑导水管周围灰质（PAG）内注射神经肽Y（NPY）后，后爪对热刺激和机械刺激的缩爪潜伏期（HWL）呈剂量依赖性增加。此外，PAG内注射Y1受体拮抗剂NPY28 - 36可减弱NPY诱导的HWL增加。结果表明，NPY在PAG的抗伤害感受中起重要作用，其中Y1受体参与其中。
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