向单神经病大鼠中脑导水管周围灰质注射降钙素基因相关肽的镇痛作用
Antinociceptive effects of calcitonin gene-related peptide injected into periaqueductal grey of rats with mononeuropathy.
作者信息
Xu S, Lundeberg T, Yu L
机构信息
Department of Physiology, College of Life Sciences, Peking University, Beijing, China.
出版信息
Brain Res. 2000 Mar 24;859(2):358-60. doi: 10.1016/s0006-8993(99)02407-5.
Intra-periaqueductal grey (PAG) injection of calcitonin gene-related peptide (CGRP) induced dose-dependent increases in hindpaw withdrawal latency (HWL) to thermal and mechanical stimulation in rats with mononeuropathy. CGRP-induced increases in HWLs were blocked by intra-PAG injection of the CGRP antagonist CGRP8-37. The results demonstrated that CGRP and CGRP receptors in PAG play an important role in antinociception in rats with mononeuropathy.
在患有单神经病的大鼠中，向中脑导水管周围灰质（PAG）内注射降钙素基因相关肽（CGRP）可使后爪对热刺激和机械刺激的缩爪潜伏期（HWL）呈剂量依赖性增加。PAG内注射CGRP拮抗剂CGRP8-37可阻断CGRP诱导的HWL增加。结果表明，PAG中的CGRP和CGRP受体在单神经病大鼠的抗伤害感受中起重要作用。
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