Maggini M, Raschetti R, Agostinis L, Cattaruzzi C, Troncon M G, Simon G
Laboratorio di Epidemiologia e Biostatistica, Istituto Superiore di Sanità, Rome, Italy.
Ann Ist Super Sanita. 1999;35(3):429-33.
Increase of acute liver injury in patients taking amoxicillin-clavulanic acid (co-amoxiclav) as compared to those taking amoxicillin has been suggested. To further investigate the potential hepatotoxicity of the two drugs a historical cohort study was conducted in the Italian region of Friuli-Venezia Giulia. One hundred and eighteen potential cases of acute liver injury were identified through the regional hospital information system and medical records were reviewed for all of them. Overall, 12 cases of acute liver injury were identified: 3 cases occurred in the amoxicillin exposure category, 2 among co-amoxiclav group, and 7 in the non-use category. The adjusted estimate of the rate ratio was 5.7 (CI 95% 1.5-22.1) among users of amoxicillin alone and 6.2 (CI 95% 1.3-29.7) among users of co-amoxiclav.
与服用阿莫西林的患者相比，服用阿莫西林-克拉维酸（复方阿莫西林）的患者急性肝损伤有所增加。为了进一步研究这两种药物的潜在肝毒性，在意大利弗留利-威尼斯朱利亚地区进行了一项历史性队列研究。通过地区医院信息系统确定了118例潜在的急性肝损伤病例，并对所有病例的病历进行了审查。总体而言，共确定了12例急性肝损伤病例：3例发生在阿莫西林暴露组，2例在复方阿莫西林组，7例在未用药组。单独使用阿莫西林的患者调整后的率比估计为5.7（95%置信区间1.5-22.1），复方阿莫西林使用者为6.2（95%置信区间1.3-29.7）。
