Garcès A, Nishimune H, Philippe J M, Pettmann B, deLapeyrière O
INSERM U.382, Institut de Biologie du Développement de Marseille (INSERM-CNRS-Univ. Méditerraneé-AP Marseille), Campus de Luminy, Marseille, France.
J Neurosci Res. 2000 Apr 1;60(1):1-9. doi: 10.1002/(SICI)1097-4547(20000401)60:1<1::AID-JNR1>3.0.CO;2-P.
In the nervous system, fibroblast growth factor-9 (FGF9) is produced mainly by neurons. By whole-mount in situ hybridization, on embryonic rat spinal cord, we observed Fgf9 expression in a subpopulation of motoneurons located in the thoracic and sacral regions of the median motor column that innervate the axial muscles. Furthermore, FGF9 prevented death of purified rat and chicken motoneurons in culture in the same concentration range as FGF2. The targets of FGF9 are more restricted than that of the other FGFs, however, because conversely to FGF1 or FGF2, FGF9 had only weak or inexistent survival effects on chicken ciliary neurons or rat DRG. FGF9 may therefore play a role as an autocrine/paracrine survival factor for motoneurons.
在神经系统中，成纤维细胞生长因子9（FGF9）主要由神经元产生。通过对胚胎大鼠脊髓进行全胚胎原位杂交，我们观察到Fgf9在位于正中运动柱胸段和骶段、支配轴肌的运动神经元亚群中表达。此外，在培养中，FGF9在与FGF2相同的浓度范围内可防止纯化的大鼠和鸡运动神经元死亡。然而，FGF9的作用靶点比其他FGFs更具局限性，因为与FGF1或FGF2相反，FGF9对鸡睫状神经元或大鼠背根神经节只有微弱的或不存在的存活作用。因此，FGF9可能作为运动神经元的自分泌/旁分泌存活因子发挥作用。
