Deng Zheng, Deng Sheng, Zhang Mu-Rong, Tang Mi-Mi
Hospital Evaluation Office, Xiangya Hospital, Central South University, Changsha, China.
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, China.
Front Pharmacol. 2019 Feb 5;10:60. doi: 10.3389/fphar.2019.00060. eCollection 2019.
Major depressive disorder (MDD) is one of the most serious diseases and now becomes a major public health problem in the world. The pathogenesis of depression remains poorly understood. Fibroblast growth factors (FGFs) belong to a large family of growth factors that are involved in brain development during early periods as well as maintenance and repair throughout adulthood. In recent years, studies have found a correlation between the members of the FGF system and depression. These signaling molecules may be expected to be biomarkers for the diagnosis and prognosis of MDD, and may provide new drug targets for the treatment of depression. Here, we reviewed the correlation between some members of the FGF system and depression.
重度抑郁症（MDD）是最严重的疾病之一，现已成为全球主要的公共卫生问题。抑郁症的发病机制仍知之甚少。成纤维细胞生长因子（FGFs）属于一大类生长因子，在早期大脑发育以及成年期的维持和修复过程中发挥作用。近年来，研究发现FGF系统成员与抑郁症之间存在关联。这些信号分子有望成为MDD诊断和预后的生物标志物，并可能为抑郁症治疗提供新的药物靶点。在此，我们综述了FGF系统一些成员与抑郁症之间的关联。
