Miyamoto S, Ogawa H, Soejima H, Takazoe K, Sakamoto T, Yoshimura M, Kugiyama K, Yasue H
Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan.
Am J Cardiol. 2000 Feb 15;85(4):494-7, A10. doi: 10.1016/s0002-9149(99)00779-1.
Using a novel laser-light scattering method, we examined platelet aggregability, especially small-sized platelet aggregates, at baseline and after spontaneous coronary spastic attacks in 14 patients with coronary spastic angina, and before and after anginal attacks during an exercise test in 11 patients with stable exertional angina. The number of small-sized platelet aggregates after coronary spastic anginal attacks increased significantly, but not in patients with stable exertional angina. These results imply that an increase in the number of small-sized platelet aggregates from coronary spasm may be a trigger for coronary thrombosis via medium- and large-sized platelet aggregates.
我们采用一种新型激光散射方法，在14例冠状动脉痉挛性心绞痛患者的基线期以及自发性冠状动脉痉挛发作后，以及在11例稳定劳力性心绞痛患者运动试验期间的心绞痛发作前后，检测了血小板聚集性，尤其是小尺寸血小板聚集体。冠状动脉痉挛性心绞痛发作后小尺寸血小板聚集体的数量显著增加，但稳定劳力性心绞痛患者中未出现这种情况。这些结果表明，冠状动脉痉挛导致的小尺寸血小板聚集体数量增加可能是通过中尺寸和大尺寸血小板聚集体引发冠状动脉血栓形成的一个触发因素。
