冠状动脉痉挛性心绞痛患者冠状动脉循环中抗氧化型低密度脂蛋白自身抗体增加。

Increased autoantibodies against oxidized low-density lipoprotein in coronary circulation in patients with coronary spastic angina.

作者信息

Ogawa H, Soejima H, Takazoe K, Miyamoto S, Kajiwara I, Shimomura H, Sakamoto T, Yoshimura M, Kugiyama K, Kimura M, Yasue H

机构信息

Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Kumamoto City, Japan.

出版信息

Angiology. 2001 Mar;52(3):167-74. doi: 10.1177/000331970105200302.

DOI:10.1177/000331970105200302

PMID:11269779

Abstract

Oxidized low-density lipoproteins are important in the progression of atherosclerosis. Autoantibodies against malondialdehyde-modified low-density lipoproteins have been reported to be predictive of the progression of atherosclerosis. This study sought to examine whether plasma levels of autoantibodies against oxidized low-density lipoprotein increase in the coronary circulation in patients with coronary spastic angina. The authors examined plasma antioxidized low-density lipoprotein antibody levels (activity unit values (AcU)/mL) simultaneously in the coronary sinus and the aortic root in 20 patients with coronary spastic angina, 23 patients with stable exertional angina, and 15 control subjects by measuring plasma levels of immunoglobulin G (IgG) autoantibodies against malondialdehyde-modified low-density lipoproteins by enzyme-linked immunosorbent assay. The plasma antioxidized low-density lipoprotein antibody levels (AcU/mL) in the coronary sinus increased in coronary spastic angina (38 +/- 16) compared with stable exertional angina (23 +/- 7) and control subjects (20 +/- 6) (p < or = 0.0001). The levels (AcU/mL) in the aortic root also increased in coronary spastic angina (33 +/- 12) compared with stable exertional angina (23 +/- 7) and control subjects (20 +/- 6) (p < 0.005). Furthermore, the coronary sinus-arterial differences of the levels (AcU/mL) were also higher in coronary spastic angina (5 +/- 9) than in stable exertional angina (0 +/- 6) and healthy subjects (-1 +/- 5) (p < 0.05). The generation of malondialdehyde-modified low-density lipoproteins is reported to be associated with atherothrombosis. These findings suggest that elevated levels of autoantibodies against malondialdehyde-modified oxidized low-density lipoproteins in coronary circulation are associated with the development of atherothrombosis from the progression of atherosclerosis rather than with the extent of coronary atherosclerosis in patients with coronary spastic angina.

摘要

氧化型低密度脂蛋白在动脉粥样硬化进展中起重要作用。据报道，抗丙二醛修饰的低密度脂蛋白自身抗体可预测动脉粥样硬化的进展。本研究旨在探讨冠状动脉痉挛性心绞痛患者冠状动脉循环中抗氧化型低密度脂蛋白自身抗体的血浆水平是否升高。作者通过酶联免疫吸附测定法测量20例冠状动脉痉挛性心绞痛患者、23例稳定劳力性心绞痛患者和15例对照者的血浆中抗丙二醛修饰的低密度脂蛋白免疫球蛋白G（IgG）自身抗体水平，同时检测冠状动脉窦和主动脉根部的血浆抗氧化型低密度脂蛋白抗体水平（活性单位值（AcU）/mL）。与稳定劳力性心绞痛患者（23±7）和对照者（20±6）相比，冠状动脉痉挛性心绞痛患者冠状动脉窦中的血浆抗氧化型低密度脂蛋白抗体水平（AcU/mL）升高（38±16）（p≤0.0001）。与稳定劳力性心绞痛患者（23±7）和对照者（20±6）相比，冠状动脉痉挛性心绞痛患者主动脉根部的水平（AcU/mL）也升高（33±12）（p＜0.005）。此外，冠状动脉痉挛性心绞痛患者的水平（AcU/mL）的冠状动脉窦-动脉差异（5±9）也高于稳定劳力性心绞痛患者（0±6）和健康受试者（-1±5）（p＜0.05）。据报道，丙二醛修饰的低密度脂蛋白的产生与动脉粥样硬化血栓形成有关。这些发现表明，冠状动脉循环中抗丙二醛修饰的氧化型低密度脂蛋白自身抗体水平升高与冠状动脉痉挛性心绞痛患者动脉粥样硬化进展导致的动脉粥样硬化血栓形成有关，而非与冠状动脉粥样硬化程度有关。