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新西方化人群中的糖尿病流行:是由于节俭基因还是未知的基因食物?

Diabetes epidemic in newly westernized populations: is it due to thrifty genes or to genetically unknown foods?

作者信息

Baschetti R

出版信息

J R Soc Med. 1998 Dec;91(12):622-5. doi: 10.1177/014107689809101203.

Abstract

Until a few decades ago, certain 'new-world' populations that kept to traditional dietary habits were virtually free from diabetes; then, after they began eating some foods that are common in Europe, the disease reached epidemic proportions. Europeans, by contrast, have a low rate of diabetes. To account for this paradox, it has been suggested that those new-world populations have a thrifty genotype, which would have conferred a selective advantage during the frequent famines of the past, while today it would be detrimental because the recently adopted foods are constantly available. Here it is proposed that thrifty genes are unlikely to exist. Both the diabetes epidemics that occur in newly westernized populations and the low rate of diabetes in Europeans can be explained by the hypothesis that Europeans, through millenary natural selection, have become adapted, albeit incompletely, to some diabetogenic foods for which humankind is genetically unequipped.

摘要

直到几十年前,某些保持传统饮食习惯的“新大陆”人群几乎没有糖尿病;后来,在他们开始食用一些欧洲常见的食物后,这种疾病就达到了流行程度。相比之下,欧洲人的糖尿病发病率较低。为了解释这一矛盾现象,有人提出那些新大陆人群具有节俭基因型,这种基因型在过去频繁发生饥荒时会带来选择优势,而如今却有害,因为最近采用的食物随时都有。本文提出节俭基因不太可能存在。新西方化人群中出现的糖尿病流行以及欧洲人糖尿病低发病率都可以用以下假说解释:欧洲人经过数千年的自然选择,已经尽管不完全地适应了一些人类在基因上无法适应的致糖尿病食物。

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