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斯洛文尼亚孕妇、性病门诊患者及静脉吸毒者中I型人类T细胞白血病/淋巴瘤病毒(HTLV-I)的血清阳性率。

Seroprevalence of human T cell leukaemia/lymphoma virus type I (HTLV-I) in pregnant women, patients attending venereological outpatient services and intravenous drug users from Slovenia.

作者信息

Poljak M, Bednarik J, Rednak K, Seme K, Kristancic L, Celan-Lucu B

机构信息

Slovenian AIDS Reference Center, Institute of Microbiology and Immunology, Medical Faculty, Ljubljana.

出版信息

Folia Biol (Praha). 1998;44(1):23-5.

PMID:10730871
Abstract

To establish current seroprevalence of human T cell leukaemia/lymphoma virus type I (HTLV-I) infection in some low- and high-risk populations from Slovenia, 10,369 and 869 serum samples collected during Slovenian 1994 unlinked surveys of human immunodeficiency viruses seroprevalence in pregnant women and patients attending venereological outpatient services, respectively, and 219 serum samples collected from Slovenian intravenous drug abusers during 1995 and 1996, were screened for the presence of anti-HTLV-I antibodies using commercial particle agglutination test Serodia HTLV-I (Fujirebio, Tokyo, Japan). Only one sample obtained from a pregnant woman was found repeatedly positive in the screening test. Presence of anti-HTLV-I antibodies in the reactive sample was undoubtedly confirmed with supplemental Western blot test. The prevalence of antibodies to HTLV-I in the Slovenian population might be somewhere between one in 10,000 (0.01%) and one in 15,000 (0.0066%), which is similar or even higher to prevalence rates in other European countries.

摘要

为确定斯洛文尼亚部分低风险和高风险人群中人类T细胞白血病/淋巴瘤病毒I型(HTLV-I)感染的当前血清流行率,分别对1994年斯洛文尼亚在孕妇和性病门诊患者中进行的人类免疫缺陷病毒血清流行率非关联调查期间收集的10369份和869份血清样本,以及1995年和1996年从斯洛文尼亚静脉注射吸毒者中收集的219份血清样本,使用商业化颗粒凝集试验Serodia HTLV-I(富士瑞必欧株式会社,东京,日本)筛查抗HTLV-I抗体的存在情况。在筛查试验中,仅发现一份来自孕妇的样本反复呈阳性。通过补充免疫印迹试验无疑证实了反应性样本中存在抗HTLV-I抗体。斯洛文尼亚人群中HTLV-I抗体的流行率可能在万分之一(0.01%)至万分之一点五(0.0066%)之间,这与其他欧洲国家的流行率相似甚至更高。

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