5号染色体三体作为小儿急性淋巴细胞白血病唯一的细胞遗传学异常

Trisomy 5 as a sole cytogenetic abnormality in pediatric acute lymphoblastic leukemia.

作者信息

Sandoval C, Mayer S P, Ozkaynak M F, Tugal O, Jayabose S

机构信息

Department of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.

出版信息

Cancer Genet Cytogenet. 2000 Apr 1;118(1):69-71. doi: 10.1016/s0165-4608(99)00176-4.

DOI:10.1016/s0165-4608(99)00176-4

PMID:10731595

Abstract

We describe a case of pediatric acute lymphoblastic leukemia (ALL) with trisomy 5 as a sole cytogenetic abnormality. A comparison is made with the two cases of adult acute lymphoblastic leukemia with trisomy 5 in the literature. This rare cytogenetic abnormality may portend an especially poor prognosis in patients with ALL.

摘要

我们描述了一例小儿急性淋巴细胞白血病（ALL），其唯一的细胞遗传学异常为5号染色体三体。并与文献中两例成年急性淋巴细胞白血病伴5号染色体三体的病例进行了比较。这种罕见的细胞遗传学异常可能预示着ALL患者的预后特别差。