Pettenati M J, Rao N, Wofford M, Shuster J J, Pullen D J, Ling M P, Steuber C P, Carroll A J
Department of Pediatrics, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina.
Cancer Genet Cytogenet. 1994 Jul 1;75(1):6-10. doi: 10.1016/0165-4608(94)90208-9.
Although trisomy 8 is the single most common numerical abnormality in acute myeloid leukemia (AML), relatively few cases with acute lymphoblastic leukemia (ALL) and trisomy 8 have been reported. We report the clinical and laboratory features of seven children with ALL and trisomy 8 as the sole cytogenetic abnormality and review nine similar cases from the literature. Among the children studied by the Pediatric Oncology Group (POG) with newly diagnosed ALL, only 0.3% had trisomy 8 as the sole abnormality. Four of our patients had T-cell ALL and three had early pre-B ALL. Presenting clinical features were typical for the respective immunophenotypes. Six of the seven children achieved complete remission. Our study suggest that trisomy 8 is an infrequent, recurring abnormality among children with ALL, which appears to be associated with a T-cell immunophenotype.
尽管8号染色体三体是急性髓系白血病（AML）中最常见的单一数值异常，但急性淋巴细胞白血病（ALL）合并8号染色体三体的病例报道相对较少。我们报告了7例ALL合并8号染色体三体且为唯一细胞遗传学异常的儿童的临床和实验室特征，并复习了文献中的9例类似病例。在小儿肿瘤协作组（POG）研究的新诊断ALL儿童中，仅有0.3%以8号染色体三体作为唯一异常。我们的4例患者为T细胞ALL，3例为早前B细胞ALL。呈现的临床特征与各自的免疫表型相符。7例儿童中有6例获得完全缓解。我们的研究表明，8号染色体三体在ALL儿童中是一种罕见的复发性异常，似乎与T细胞免疫表型相关。
