Cox M C, Scanzani A, Del Poeta G, Venditti A, Panetta P, Derme V, Sgro R, Masi M, Amadori S
Department of Hematology, "Tor Vergata" University, St. Eugenio Hospital, Rome, Italy.
Cancer Genet Cytogenet. 2000 Apr 1;118(1):76-9. doi: 10.1016/s0165-4608(99)00179-x.
Acute myeloid leukemia with minimal signs of myeloid differentiation (AML-M0) is a recent addition to the FAB group classification. Chromosome data is scarce, but existing reports describe a high incidence of complex karyotypes and myelodysplastic syndrome-like chromosome alterations, while single chromosome translocations have rarely been reported. We describe the case of a 60-year-old woman diagnosed with AML-M0 with a novel translocation t(11;12)(q23-24;q24) as the sole karyotypic marker. Fluorescence in situ hybridization analysis to assess MLL gene splitting did not show rearrangement of this oncogene.
伴有极少髓系分化迹象的急性髓系白血病（AML-M0）是FAB组分类中的新增类型。染色体数据稀缺，但现有报告描述了复杂核型和骨髓增生异常综合征样染色体改变的高发生率，而单染色体易位很少被报道。我们描述了一例60岁女性被诊断为AML-M0的病例，其具有一种新的易位t(11;12)(q23-24;q24)作为唯一的核型标记。用于评估MLL基因断裂的荧光原位杂交分析未显示该癌基因的重排。
