通过荧光原位杂交鉴定MLL基因参与t(10;11)(q22;q23)和t(8;11)(q24;q23)。
Involvement of MLL gene in a t(10;11)(q22;q23) and a t(8;11)(q24;q23) identified by fluorescence in situ hybridization.
作者信息
Aventín A, La Starza R, Martínez C, Wlodarska I, Boogaerts M, Van den Berghe H, Mecucci C
机构信息
Institute of Hematology, University of Perugia, Italy.
出版信息
Cancer Genet Cytogenet. 1999 Jan 1;108(1):48-52. doi: 10.1016/s0165-4608(98)00110-1.
PMID:9973924
Abstract
We describe two cases of acute myeloblastic leukemia, classified as M4 and M5 in the French-American-British nomenclature, with an 11q23 rearrangement at karyotypic analysis. The involvement of the MLL gene with two new partner loci on chromosome 10q22 and 8q24, respectively, was demonstrated by fluorescence in situ hybridization using a YAC clone B22B2L.
摘要
我们描述了两例急性髓细胞白血病，根据法美英命名法分类为M4和M5，核型分析显示有11q23重排。使用YAC克隆B22B2L通过荧光原位杂交证实了MLL基因分别与染色体10q22和8q24上的两个新的伙伴基因座发生了关联。
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