Satoh J, Eguchi Y, Narukiyo T, Mizuta T, Kobayashi O, Kawai M, Nonaka I, Kuroda Y
Department of Internal Medicine, Saga Medical School.
Intern Med. 2000 Feb;39(2):176-81. doi: 10.2169/internalmedicine.39.176.
We describe a 61-year-old man presenting with necrotizing myopathy associated with chronic active hepatitis due to hepatitis C virus (HCV) infection. Thirteen patients with HCV-associated myopathy have been reported previously. In most of these cases, varying degrees of inflammatory changes were observed in the muscle tissue. In 2 patients, myopathy developed after initiation of interferon therapy for chronic HCV hepatitis. Our case was unusual due to long-standing elevation of creatine kinase values which improved following interferon therapy and the non-inflammatory features of the muscle tissue where the HCV RNA minus strand, a marker for replicative intermediates of the virus, was undetectable. The association of myopathy with HCV infection might represent a unique clinical entity, although the underlying pathological mechanisms remain unknown.
我们描述了一名61岁男性，其患有与丙型肝炎病毒（HCV）感染所致慢性活动性肝炎相关的坏死性肌病。此前已有13例HCV相关性肌病患者的报道。在大多数这些病例中，肌肉组织中观察到不同程度的炎症变化。在2例患者中，慢性HCV肝炎患者在开始干扰素治疗后出现肌病。我们的病例不同寻常，因为肌酸激酶值长期升高，在干扰素治疗后有所改善，且肌肉组织无炎症特征，在该组织中未检测到作为病毒复制中间体标志物的HCV RNA负链。肌病与HCV感染的关联可能代表一种独特的临床实体，尽管其潜在病理机制尚不清楚。
