keith J C, Pijnenborg R, Luyten C, Spitz B, Schaub R, Van Assche F A
Preclinical Research and Development, Genetics Institute, Inc., Cambridge, MA 02140, USA.
Eur J Obstet Gynecol Reprod Biol. 2000 Mar;89(1):19-25. doi: 10.1016/s0301-2115(99)00154-2.
The aim of this study was the measurement of maternal serum levels of M-CSF throughout pregnancy, in a low risk obstetrical population, to examine the relationship of M-CSF and pregnancy outcome.
Maternal serum was obtained at various stages of pregnancy and post partum, M-CSF levels were measured by ELISA, pertinent clinical data tabulated, and pregnancy outcome was determined.
In 564 pregnancies studied, 22% of 260 nulliparous pregnancies and 10% of 304 multiparous pregnancies were hypertensive. Preeclampsia occurred in 1.5% of nulliparous and in 1% of the multiparous women. In apparently normal pregnancies with good outcome, M-CSF levels rose throughout pregnancy. No cases of preeclampsia occurred if maternal serum M-CSF levels increased more than 100% throughout pregnancy.
This study suggests that absolute levels and relative changes in maternal serum M-CSF levels during pregnancy are associated with adverse pregnancy outcomes.
本研究旨在测定低危产科人群整个孕期母体血清中巨噬细胞集落刺激因子（M-CSF）的水平，以探讨M-CSF与妊娠结局之间的关系。
在孕期及产后的不同阶段采集母体血清，采用酶联免疫吸附测定法（ELISA）测定M-CSF水平，将相关临床数据制成表格，并确定妊娠结局。
在研究的564例妊娠中，260例初产妇中有22%发生高血压，304例经产妇中有10%发生高血压。初产妇中1.5%发生先兆子痫，经产妇中1%发生先兆子痫。在结局良好的明显正常妊娠中，M-CSF水平在整个孕期均升高。如果孕期母体血清M-CSF水平升高超过100%，则无先兆子痫病例发生。
本研究表明，孕期母体血清M-CSF水平的绝对水平和相对变化与不良妊娠结局相关。
