Department of Gynecology and Obstetrics, Changchun University of Chinese Medicine Affiliated Hospital, Jilin, China.
Department of Gynecology, Changchun University of Chinese Medicine Affiliated Hospital, Jilin, China.
Med Princ Pract. 2024;33(5):462-470. doi: 10.1159/000539619. Epub 2024 Jun 3.
This study aimed to assess the predictive value of macrophage colony-stimulating factor (M-CSF) in the first trimester for hypertensive disorders complicating pregnancy (HDCP) and its association with disease severity and adverse pregnancy outcomes. HDCP pose significant risks to both maternal health and fetal health. M-CSF is implicated in the pathogenesis of HDCP by promoting inflammation and endothelial damage.
Serum levels of M-CSF were measured using an enzyme-linked immunosorbent assay, and clinical characteristics and pregnancy outcomes were compared between groups.
Pregnant women with HDCP had significantly higher levels of proteinuria, systolic blood pressure, and diastolic blood pressure compared to those with normal pregnancy. Among patients with HDCP, the severity of disease correlated positively with serum levels of M-CSF. Furthermore, M-CSF levels in the first trimester were significantly associated with adverse pregnancy outcomes. The findings suggest that M-CSF may serve as a potential biomarker for predicting HDCP and its severity, as well as adverse pregnancy outcomes.
Early detection and monitoring of M-CSF levels could aid in identifying high-risk pregnancies and implementing appropriate interventions to improve maternal and fetal outcomes.
本研究旨在评估巨噬细胞集落刺激因子（M-CSF）在早孕期对妊娠合并高血压疾病（HDCP）的预测价值，及其与疾病严重程度和不良妊娠结局的关系。HDCP 对母婴健康均构成重大威胁。M-CSF 通过促进炎症和内皮损伤而参与 HDCP 的发病机制。
采用酶联免疫吸附试验检测 M-CSF 血清水平，并比较各组间的临床特征和妊娠结局。
与正常妊娠相比，HDCP 孕妇的蛋白尿、收缩压和舒张压均显著升高。在 HDCP 患者中，疾病严重程度与 M-CSF 血清水平呈正相关。此外，早孕期 M-CSF 水平与不良妊娠结局显著相关。这些发现提示 M-CSF 可能作为预测 HDCP 及其严重程度和不良妊娠结局的潜在生物标志物。
早期检测和监测 M-CSF 水平有助于识别高危妊娠，并实施适当干预以改善母婴结局。
