Cooper G S, Baird D D, Weinberg C R, Ephross S A, Sandler D P
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangel Park, NC 27709, USA.
Am J Epidemiol. 2000 Mar 15;151(6):620-3. doi: 10.1093/oxfordjournals.aje.a010250.
Several studies have reported increased mortality risk with early natural menopause. More recently, mortality risk was reported to be reduced among women who gave birth at age > or =40 years. The association between reproductive history and mortality was explored among 826 women in a prospective study involving 18,959 person-years of follow-up (from age 50 to 1990-1991) and 108 deaths. After adjustment for age and other covariates, the risk ratio among parous women was 1.53 (95% confidence interval: 0.58, 4.07) for natural menopause at age < or =45 years compared with > or =51 years. In contrast to a previous report, however, the highest estimated mortality risk was seen among women who gave birth in their forties (adjusted risk ratio = 2.14, 95% confidence interval: 1.05, 4.38) compared with having a last birth at ages 30-34 years.
多项研究报告称，自然绝经过早会增加死亡风险。最近又有报告称，40岁及以上生育的女性死亡风险降低。在一项前瞻性研究中，对826名女性进行了生殖史与死亡率之间关联的探究，该研究随访了18959人年（从50岁至1990 - 1991年），有108例死亡。在对年龄和其他协变量进行调整后，与51岁及以上自然绝经相比，45岁及以下自然绝经的经产妇风险比为1.53（95%置信区间：0.58，4.07）。然而，与之前的一份报告不同的是，与30 - 34岁最后一次生育相比，40多岁生育的女性估计死亡风险最高（调整后风险比 = 2.14，95%置信区间：1.05，4.38）。
