Snowdon D A, Kane R L, Beeson W L, Burke G L, Sprafka J M, Potter J, Iso H, Jacobs D R, Phillips R L
Division of Epidemiology, University of Minnesota School of Public Health, Minneapolis 55455.
Am J Public Health. 1989 Jun;79(6):709-14. doi: 10.2105/ajph.79.6.709.
The relation between age at natural menopause and all-cause mortality was investigated in a sample of 5,287 White women, ages 55 to 100 years, naturally-postmenopausal, Seventh-day Adventists who had completed mailed questionnaires in 1976. The age-adjusted odds ratio of death during 1976-82 in women with natural menopause before age 40 was 1.95 (95% confidence interval = 1.24, 3.07), compared to the reference group of women reporting natural menopause at ages 50 to 54. Corresponding odds ratios of death were 1.39 (95% CI = 1.06, 1.81) for natural menopause at ages 40 to 44, and 1.03 (95% CI = 0.84, 1.25) for natural menopause at ages 45 to 49. Among 3,166 White, 55- to 100-year-old, surgically-postmenopausal, Adventist women, there was no relation between age at surgical menopause and mortality. Logistic regression analyses indicated that findings from this study were apparently not due to confounding by smoking, over- or underweight, reproductive history, or replacement estrogen use.
在一个由5287名年龄在55至100岁之间、自然绝经的白人女性组成的样本中，研究了自然绝经年龄与全因死亡率之间的关系。这些女性都是基督复临安息日会信徒，于1976年完成了邮寄问卷调查。与报告自然绝经年龄在50至54岁的女性参考组相比，自然绝经年龄在40岁之前的女性在1976 - 1982年期间死亡的年龄调整优势比为1.95（95%置信区间 = 1.24, 3.07）。自然绝经年龄在40至44岁的女性相应的死亡优势比为1.39（95%置信区间 = 1.06, 1.81），自然绝经年龄在45至49岁的女性相应的死亡优势比为1.03（95%置信区间 = 0.84, 1.25）。在3166名年龄在55至100岁之间、接受过手术绝经的白人基督复临安息日会女性中，手术绝经年龄与死亡率之间没有关系。逻辑回归分析表明，该研究的结果显然不是由于吸烟、超重或体重不足、生殖史或使用替代雌激素造成的混杂因素导致的。
