Klugbauer N, Dai S, Specht V, Lacinová L, Marais E, Bohn G, Hofmann F
Institut für Pharmakologie und Toxikologie der Technischen Universität München, Biedersteiner Str. 29, 80802, Munich, Germany.
FEBS Lett. 2000 Mar 24;470(2):189-97. doi: 10.1016/s0014-5793(00)01306-5.
The gamma subunit was initially identified as an auxiliary subunit of the skeletal muscle calcium channel complex. Evidence for the existence of further gamma subunits arose following the characterization of a genetic defect that induces epileptic seizures in stargazer mice. We present here the first account of a family of at least five putative gamma subunits that are predominantly expressed in brain. The gamma-2 and gamma-4 subunits shift the steady-state inactivation curve to more hyperpolarized potentials upon coexpression with the P/Q type alpha(1A) subunit. The coexpression of the gamma-5 subunit accelerates the time course of current activation and inactivation of the alpha(1G) T-type calcium channel.
γ亚基最初被鉴定为骨骼肌钙通道复合物的辅助亚基。在对一种导致凝视小鼠癫痫发作的遗传缺陷进行表征后，出现了存在更多γ亚基的证据。我们在此首次报道了一个至少由五个推定的γ亚基组成的家族，它们主要在大脑中表达。γ-2和γ-4亚基与P/Q型α(1A)亚基共表达时，会将稳态失活曲线移向更超极化的电位。γ-5亚基的共表达加速了α(1G) T型钙通道电流激活和失活的时间进程。
