Jänig W, Khasar S G, Levine J D, Miao F J
Physiologisches Institut, Christian-Albrechts-Universität zu Kiel, Germany.
Prog Brain Res. 2000;122:273-87. doi: 10.1016/s0079-6123(08)62145-7.
We have shown that activity in subdiaphragmatic vagal afferents modulates mechanical hyperalgesic behavior in the rat. Subdiaphragmatic vagotomy decreases paw-withdrawal threshold to mechanical stimulation (baseline and after intradermal injection of bradykinin), thus enhancing mechanical hyperalgesic behavior. Most of this decrease is generated by an endocrine signal released by the adrenal medullae because denervation or removal of the adrenal medullae prevents or reverses these changes. This novel mechanism may imply that: (a) the brain is able to regulate sensitivity of nociceptors all over the body by a neuroendocrine mechanisms, (b) sensitivity of nociceptors can be influenced by changes in parts of the body which are remote from the location of the sensitized nociceptors and (c) circulating catecholamines can influence nociceptors in a way which is different from those reported so far (see Jänig and McLachlan, 1994; Jänig, 1996a; Jänig et al., 1996).
我们已经表明，膈下迷走神经传入纤维的活动可调节大鼠的机械性痛觉过敏行为。膈下迷走神经切断术会降低对机械刺激的爪部退缩阈值（基线以及皮内注射缓激肽后），从而增强机械性痛觉过敏行为。这种降低大部分是由肾上腺髓质释放的一种内分泌信号所引起的，因为去神经支配或切除肾上腺髓质可预防或逆转这些变化。这种新机制可能意味着：(a)大脑能够通过神经内分泌机制调节全身伤害感受器的敏感性，(b)伤害感受器的敏感性可受到远离致敏伤害感受器部位的身体部位变化的影响，以及(c)循环中的儿茶酚胺能够以一种与迄今所报道的方式不同的方式影响伤害感受器（见扬尼格和麦克拉克伦，1994年；扬尼格，1996a；扬尼格等人，1996年）。
