Service d'hépato-Gastroentérologie, Grenoble Institut Neurosciences, Université Grenoble-Alpes, Grenoble, France.
Inflammopharmacology. 2024 Apr;32(2):1005-1015. doi: 10.1007/s10787-024-01446-7. Epub 2024 Mar 21.
The gut and the brain communicate bidirectionally through the autonomic nervous system. The vagus nerve is a key component of this gut-brain axis, and has numerous properties such as anti-inflammatory, antinociceptive, anti-depressive effects. A perturbation of this gut-brain communication is involved in the pathogeny of functional digestive disorders, such as irritable bowel syndrome, and inflammatory bowel diseases. Stress plays a role in the pathogeny of these diseases, which are biopsychosocial models. There are presently unmet needs of pharmacological treatments of these chronic debilitating diseases. Treatments are not devoid of side effects, cost-effective, do not cure the diseases, can lose effects over time, thus explaining the poor satisfaction of patients, their lack of compliance, and their interest for non-drug therapies. The gut-brain axis can be targeted for therapeutic purposes in irritable bowel syndrome and inflammatory bowel disease through non-drug therapies, such as hypnosis and vagus nerve stimulation, opening up possibilities for responding to patient expectations.
肠道和大脑通过自主神经系统双向交流。迷走神经是这个肠道-大脑轴的关键组成部分，具有许多特性，如抗炎、镇痛、抗抑郁作用。这种肠道-大脑通讯的紊乱与功能性消化紊乱的发病机制有关，如肠易激综合征和炎症性肠病。压力在这些疾病的发病机制中起作用，这些疾病是生物心理社会模型。目前，这些慢性致残性疾病的药物治疗存在未满足的需求。治疗并非没有副作用、不经济实惠、不能治愈疾病、随着时间的推移可能会失去效果，这也解释了患者满意度低、不遵医嘱以及他们对非药物治疗的兴趣。通过非药物治疗，如催眠和迷走神经刺激，可以针对肠易激综合征和炎症性肠病的治疗目的靶向肠道-大脑轴，为满足患者的期望提供了可能。
