大手术只会使血管内皮生长因子的血清水平暂时升高。

Major surgery increases serum levels of vascular endothelial growth factor only temporarily.

作者信息

Bondestam J, Salven P, Jääskela-Saari H, Ikonen T, Lepäntalo M, Mattila S, Joensuu H

机构信息

Department of Oncology, Helsinki University Central Hospital, Finland.

出版信息

Am J Surg. 2000 Jan;179(1):57-9. doi: 10.1016/s0002-9610(99)00253-6.

DOI:10.1016/s0002-9610(99)00253-6

PMID:10737580

Abstract

BACKGROUND

Vascular endothelial growth factor (VEGF) is a hypoxia-induced endothelial cell-specific mitogen, which is angiogenic in vivo and up-regulated in several malignancies. VEGF can be used as a prognostic marker, but the effect of surgical trauma on serum VEGF (S-VEGF) concentrations is unknown and might reduce the value of VEGF as a serum marker.

METHODS

We monitored S-VEGF levels by enzyme-linked immunosorbent assay in patients undergoing surgery.

RESULTS

Eighteen patients with major surgery had slightly elevated S-VEGF compared with the preoperative level (median 9.5 pg/mL) on the first (median 35 pg/mL; P = 0.0002) and third (median 19 pg/mL; P = 0.004) postoperative day, but not in later samples. The levels measured in 8 patients after minor surgery did not differ from the preoperative levels (P = 0.14).

CONCLUSIONS

Even major surgery is associated only with a slight and transient increase in S-VEGF levels, and, therefore, is unlikely to interfere markedly with the use of VEGF as a prognostic marker.

摘要

背景

血管内皮生长因子（VEGF）是一种由缺氧诱导产生的、对内皮细胞具有特异性的促有丝分裂原，它在体内具有血管生成作用，且在多种恶性肿瘤中表达上调。VEGF可作为一种预后标志物，但手术创伤对血清VEGF（S-VEGF）浓度的影响尚不清楚，这可能会降低VEGF作为血清标志物的价值。

方法

我们采用酶联免疫吸附测定法对接受手术的患者的S-VEGF水平进行监测。

结果

18例接受大手术的患者在术后第一天（中位数35 pg/mL；P = 0.0002）和第三天（中位数19 pg/mL；P = 0.004）时，其S-VEGF水平相较于术前水平（中位数9.5 pg/mL）略有升高，但在之后的样本中未出现此情况。8例接受小手术的患者所测得的S-VEGF水平与术前水平无差异（P = 0.14）。