采用可见分光光度法测定药物制剂中的甲硫哒嗪。
Determination of methotrimeprazine in pharmaceutical preparations by visible spectrophotometry.
作者信息
Kedor-Hackmann E R, Prado M S, Santoro M I
机构信息
Faculty of Pharmaceutical Sciences, University of São Paulo, Brazil.
出版信息
Drug Dev Ind Pharm. 2000 Mar;26(3):261-6. doi: 10.1081/ddc-100100354.
A spectrophotometric method is described for determination of methotrimeprazine (levomepromazine). The aim of this work was to develop a simple, rapid, precise, and accurate visible spectrophotometric method for determination of methotrimeprazine in tablet, oral solution, and injection. The method is based on methotrimeprazine reaction with bromophenol blue, resulting in a stable, light yellow-green ion-pair complex that, after extraction with chloroform, presented maximum absorption at 409 nm. Beer's law was obeyed in the concentration range from 5.0 to 25.0 micrograms/ml. The proposed standardized method was applied to commercially available and simulated samples. The accuracy of the method was confirmed by recovery tests.
本文描述了一种用于测定甲硫替平（左美丙嗪）的分光光度法。这项工作的目的是开发一种简单、快速、精密且准确的可见分光光度法，用于测定片剂、口服液和注射液中的甲硫替平。该方法基于甲硫替平与溴酚蓝的反应，生成一种稳定的浅黄绿色离子对络合物，用氯仿萃取后，在409nm处呈现最大吸收。在5.0至25.0微克/毫升的浓度范围内符合比尔定律。所提出的标准化方法应用于市售样品和模拟样品。通过回收率试验证实了该方法的准确性。
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