Puzanowska-Tarasiewicz H, Misiuk W, Mielech-Łukasiewicz K, Kuźmicka L
Institute of Chemistry, University of Białystok, Hurtowa 1, Białystok 15-399, Poland.
Indian J Pharm Sci. 2009 Jan;71(1):8-18. doi: 10.4103/0250-474X.51942.
Psychotropic drugs are an important family of compounds from a medical point of view. Their application in therapy requires methods for the determination in pharmaceutical dosage forms and body fluids. Several methods for their analysis have been reported in the literature. Among the methods, spectrophotometric and electrochemical are very useful for the determination of the drugs. Some of the spectrophotometric methods are based on the formation of the binary and ternary compounds with complexes of metals. The formed compounds are sparingly soluble in water, but quantitatively extracted from aqueous phase into organic solvents and the extracts are intensely colored and stable for a few days. These complexes have been employed in pharmaceutical analysis. The electrochemical procedures are very useful in determination of the psychotropic substances in pharmaceutical preparations.
从医学角度来看，精神药物是一类重要的化合物。它们在治疗中的应用需要测定药物剂型和体液的方法。文献中已经报道了几种分析它们的方法。在这些方法中，分光光度法和电化学法对于药物的测定非常有用。一些分光光度法基于与金属络合物形成二元和三元化合物。形成的化合物在水中微溶，但可从水相定量萃取到有机溶剂中，萃取物颜色深且在几天内稳定。这些络合物已用于药物分析。电化学方法在测定药物制剂中的精神活性物质方面非常有用。
