Ly D H, Lockhart D J, Lerner R A, Schultz P G
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Science. 2000 Mar 31;287(5462):2486-92. doi: 10.1126/science.287.5462.2486.
Messenger RNA levels were measured in actively dividing fibroblasts isolated from young, middle-age, and old-age humans and humans with progeria, a rare genetic disorder characterized by accelerated aging. Genes whose expression is associated with age-related phenotypes and diseases were identified. The data also suggest that an underlying mechanism of the aging process involves increasing errors in the mitotic machinery of dividing cells in the postreproductive stage of life. We propose that this dysfunction leads to chromosomal pathologies that result in misregulation of genes involved in the aging process.
在从年轻人、中年人和老年人以及患有早衰症（一种以加速衰老为特征的罕见遗传疾病）的人类中分离出的活跃分裂的成纤维细胞中，测量了信使核糖核酸（mRNA）水平。确定了那些其表达与年龄相关表型和疾病相关的基因。数据还表明，衰老过程的一个潜在机制涉及在生命的生殖后期，分裂细胞的有丝分裂机制中错误增加。我们提出，这种功能障碍会导致染色体病变，从而导致参与衰老过程的基因调控失调。
