Uldall K K, Ryan R, Berghuis J P, Harris V L
Center for Health Education and Research, University of Washington, Seattle, Washington, USA.
AIDS Patient Care STDS. 2000 Feb;14(2):95-100. doi: 10.1089/108729100318037.
The purpose of this study was to examine the relationship between delirium and death in AIDS patients. Forty-one patients admitted to a combination skilled nursing and assisted-living facility in 1994 were included in the retrospective chart review. Patients were grouped according to the presence versus absence of delirium during the first week of admission. Demographic characteristics and medical morbidity of the two groups were compared using the Chi-square statistic. Kaplan-Meier survival analysis was used to estimate survival functions during the study period for the delirious and nondelirious groups. Nine patients (22%) were found to have an episode of delirium in the first week of admission. There were no significant differences in demographic characteristics or medical morbidity between the delirious and nondelirious groups. Median days from admission to death for those with delirium (10 days) versus those without delirium (135 days) was significantly different (log rank = 19.03; p < 0.0001). Authors concluded that delirium is a marker for decreased survival in this sample of AIDS patients. Future research needs to demonstrate whether improved care of AIDS patients can prevent delirium or limit adverse outcomes associated with it.
本研究的目的是探讨艾滋病患者谵妄与死亡之间的关系。1994年入住一家集专业护理与辅助生活服务于一体机构的41名患者纳入了回顾性病历审查。根据入院第一周是否存在谵妄对患者进行分组。使用卡方统计量比较两组的人口统计学特征和医疗发病率。采用Kaplan-Meier生存分析来估计研究期间谵妄组和非谵妄组的生存函数。发现9名患者（22%）在入院第一周出现谵妄发作。谵妄组和非谵妄组在人口统计学特征或医疗发病率方面无显著差异。谵妄患者从入院到死亡的中位天数（10天）与无谵妄患者（135天）有显著差异（对数秩 = 19.03；p < 0.0001）。作者得出结论，谵妄是该组艾滋病患者生存下降的一个标志。未来的研究需要证明改善艾滋病患者的护理是否能够预防谵妄或限制与之相关的不良后果。
