Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
J Neurovirol. 2012 Aug;18(4):277-90. doi: 10.1007/s13365-012-0108-z. Epub 2012 May 30.
Persons over age 50 are not only aging with human immunodeficiency virus (HIV) infection but also represent a high proportion of new HIV infections. Neuropsychiatric symptoms, including depression, cognitive impairment, and substance abuse, are very common in individuals infected with HIV. However, there is little understanding of the relationship between these HIV-related comorbid conditions in newly infected elderly patients compared to uninfected elderly and those who have survived after 20 years of HIV/AIDS. We summarize the current theories and research that link aging and HIV with psychiatric illnesses and identify emerging areas for improved research, treatment, and patient care.
50 岁以上的人群不仅会随着人类免疫缺陷病毒（HIV）感染而衰老，而且还占新感染 HIV 的很大比例。神经精神症状，包括抑郁、认知障碍和物质滥用，在感染 HIV 的个体中非常常见。然而，与未感染的老年人以及那些在 HIV/AIDS 感染 20 年后幸存下来的人相比，人们对新感染的老年患者中这些与 HIV 相关的合并症之间的关系知之甚少。我们总结了将衰老和 HIV 与精神疾病联系起来的现有理论和研究，并确定了改善研究、治疗和患者护理的新领域。
