Franch T, Gerdes K
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M, 5230, Denmark.
Curr Opin Microbiol. 2000 Apr;3(2):159-64. doi: 10.1016/s1369-5274(00)00069-2.
Conventional antisense RNAs, such as those controlling plasmid replication and maintenance, inhibit the function of their target RNAs rapidly and efficiently. Novel findings show that a common U-turn loop structure mediates fast RNA pairing in the majority of these RNA controlled systems. Usually, an antisense RNA regulates a single, cognate target RNA only. Recent reports, however, show that antisense RNAs can act as promiscuous regulators that control multiple genes in concert to integrate complex physiological responses in Escherichia coli.
传统的反义RNA，如那些控制质粒复制和维持的反义RNA，能快速且高效地抑制其靶RNA的功能。新的研究结果表明，在大多数这些RNA控制系统中，一种常见的U型环结构介导了快速的RNA配对。通常，一条反义RNA仅调控单个同源靶RNA。然而，最近的报道显示，反义RNA可以作为一种混杂的调控因子，协同控制多个基因，以整合大肠杆菌中的复杂生理反应。
