Khedun S M, Moodley J, Naicker T, Maharaj B
Department of Experimental and Clinical Pharmacology, University of Natal, Durban.
S Afr Med J. 2000 Feb;90(2):156-60.
To determine the current management of hypertensive disorders of pregnancy in South Africa.
A postal questionnaire was sent to 600 South African obstetricians.
The response rate was 72% (432/600), with 425 questionnaires suitable for analysis. South African obstetricians disagree on the definitions of various hypertensive disorders of pregnancy. Methyldopa was the antihypertensive used most frequently for the treatment of mild to moderate hypertension (diastolic blood pressure between 90 and 109 mmHg), while intravenous dihydralazine was preferred in severe hypertension (diastolic blood pressure > or = 110 mmHg and proteinuria > or = +2). To stop convulsions in eclampsia, 256 respondents (60%) said they would use diazepam, 28 (11%) said they would continue with a diazepam infusion, and the remaining 228 (89%) preferred magnesium sulphate (MgSO4) to prevent further convulsions. The intramuscular route was the preferred method of administration for MgSO4. In cases of eclampsia, 273 respondents (64%) said they would use intravenous dihydralazine to lower high blood pressure (> or = 160/110 mmHg) and proteinuria; 98 respondents (23%) said they would use methyldopa, 38 (9%) nifedipine, and 8 (2%) apresoline. Eight (2%) said they would not use antihypertensives. In patients with severe pre-eclampsia and impending eclampsia, 330 respondents (78%) said they would use MgSO4 as prophylaxis, 46 (11%) diazepam, and 6 (1.4%) phenobarbitone. Forty-three of the respondents did not prescribe prophylactic anticonvulsant therapy. To prevent pre-eclampsia, 247 of the respondents (58%) said they would prescribe low-dose aspirin.
This study demonstrates that South African obstetricians show great uniformity in terms of the treatment of hypertensive disorders of pregnancy.
确定南非妊娠期高血压疾病的当前管理方式。
向600名南非产科医生发送了邮政问卷。
回复率为72%(432/600),其中425份问卷适合分析。南非产科医生对各种妊娠期高血压疾病的定义存在分歧。甲基多巴是治疗轻度至中度高血压(舒张压在90至109 mmHg之间)最常用的降压药,而重度高血压(舒张压≥110 mmHg且蛋白尿≥+2)时则首选静脉注射双肼屈嗪。为子痫患者止惊时,256名受访者(60%)表示会使用地西泮,28名(11%)表示会持续静脉输注地西泮,其余228名(89%)则更倾向于使用硫酸镁(MgSO4)以预防进一步惊厥。肌肉注射途径是硫酸镁的首选给药方式。对于子痫病例,273名受访者(64%)表示会使用静脉注射双肼屈嗪来降低高血压(≥160/110 mmHg)和蛋白尿;98名受访者(23%)表示会使用甲基多巴,38名(9%)使用硝苯地平,8名(2%)使用阿普利素灵。8名(2%)表示不会使用降压药。在重度子痫前期和即将发生子痫的患者中,330名受访者(78%)表示会使用硫酸镁作为预防措施,46名(11%)使用地西泮,6名(1.4%)使用苯巴比妥。43名受访者未开预防性抗惊厥治疗药物。为预防子痫前期,247名受访者(58%)表示会开低剂量阿司匹林。
本研究表明,南非产科医生在妊娠期高血压疾病的治疗方面表现出很大的一致性。