Vickery M C, Harold N, Bej A K
Department of Biology and Department of Criminal Justice and Forensic Sciences, University of Alabama at Birmingham, Birmingham, AL 35294-1170, USA.
Lett Appl Microbiol. 2000 Mar;30(3):258-62. doi: 10.1046/j.1472-765x.2000.00707.x.
Arbitrarily-primed-polymerase chain reaction (AP-PCR) DNA fingerprints were generated for 10 Vibrio vulnificus strains isolated from patients who became infected and died between 1993 and 1996 as a result of consuming raw oysters. Analysis of the DNA fingerprints with gel imaging and cluster analysis software revealed significant genetic heterogeneity among these strains, suggesting that V. vulnificus has a high degree of variation in its genomic organization, and that multiple pathogenic strains with greatly diverse genomic arrangements, rather than a single type of infective strain or serogroup, caused these infections.
对1993年至1996年间因食用生牡蛎而感染并死亡的患者所分离出的10株创伤弧菌菌株进行了任意引物聚合酶链反应（AP-PCR）DNA指纹图谱分析。使用凝胶成像和聚类分析软件对DNA指纹图谱进行分析，结果显示这些菌株之间存在显著的遗传异质性，这表明创伤弧菌的基因组组织具有高度变异性，并且是多种基因组排列差异很大的致病菌株，而非单一类型的感染菌株或血清群导致了这些感染。
