Condorelli D F, Belluardo N, Trovato-Salinaro A, Mudò G
Department of Chemical Sciences, University of Catania, Viale A Doria 6 95125, Catania, Italy.
Brain Res Brain Res Rev. 2000 Apr;32(1):72-85. doi: 10.1016/s0165-0173(99)00068-5.
Cx36 is the first mammalian member of a novel subgroup of the connexin family, characterized by a long cytoplasmic loop, a peculiar gene structure and a preferential expression in cell types of neural origin. In the present review we summarize the evidence in favour of its predominant expression in neuronal cells in the mammalian central nervous system, such as results from experiments with specific neurotoxins and co-localization of Cx36 mRNA and a neuronal marker. We also report a detailed description of Cx36 mRNA distribution in the rat and human central nervous system by in situ hybridization and, for each brain region, we correlate the novel findings with previous morphological or functional demonstrations of neuronal gap junctions in the same area.
Cx36是连接蛋白家族一个新亚组的首个哺乳动物成员，其特征为具有一个长的胞质环、独特的基因结构以及在神经源性细胞类型中优先表达。在本综述中，我们总结了支持其在哺乳动物中枢神经系统神经元细胞中优势表达的证据，比如来自特定神经毒素实验的结果以及Cx36 mRNA与一种神经元标志物的共定位。我们还通过原位杂交详细描述了Cx36 mRNA在大鼠和人类中枢神经系统中的分布，并且对于每个脑区，我们将这些新发现与同一区域先前关于神经元缝隙连接的形态学或功能学证明进行关联。
