神经元Cx36间隙连接通道阻断的潜在抗癫痫发生作用。
The potential antiepileptogenic effect of neuronal Cx36 gap junction channel blockage.
作者信息
Wang Guangliang, Wu Xuemei
机构信息
Department of Cardiology, Far Eastern Horizon Hospital, Linghai, Liaoning, People's Republic of China.
Department of Pediatric Neurology, First Hospital of Jilin University, 1 Xinmin Street, Changchun 130000, Jilin, People's Republic of China.
出版信息
Transl Neurosci. 2021 Jan 22;12(1):46-51. doi: 10.1515/tnsci-2021-0008. eCollection 2021 Jan 1.
Epilepsy is one of the most prevalent neurological disorders and can result in neuronal injury and degeneration. Consequently, research into new antiepileptic drugs capable of providing protection against neuronal injury and degeneration is extremely important. Neuronal Cx36 gap junction channels have been found to play an important role in epilepsy; thus, pharmacological interference using Cx36 gap junction channel blockers may be a promising strategy for disrupting the synchronization of neurons during seizure activity and protecting neurons. Based on these promising findings, several and studies are ongoing and the first encouraging results have been published. The results bring hope that neurons can be protected from injury and degeneration in patients with epilepsy, which is currently impossible.
癫痫是最常见的神经系统疾病之一，可导致神经元损伤和变性。因此，研究能够提供抗神经元损伤和变性保护作用的新型抗癫痫药物极为重要。已发现神经元Cx36间隙连接通道在癫痫中起重要作用；因此，使用Cx36间隙连接通道阻滞剂进行药理学干预可能是在癫痫发作活动期间破坏神经元同步性并保护神经元的一种有前景的策略。基于这些有前景的发现，多项研究正在进行中，且已发表了首批令人鼓舞的结果。这些结果带来了希望，即癫痫患者的神经元能够免受损伤和变性，而这在目前是无法实现的。
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