圆窗微导管给药微剂量庆大霉素：梅尼埃病伴耳鸣治疗结果

Round-Window Microcatheter-Administered Microdose Gentamicin: Results from Treatment of Tinnitus Associated with Menière's Disease.

作者信息

DeCicco MJ, Hoffer ME, Kopke RD, Wester D, Allen KA, Gottshall K, O'Leary MJ

机构信息

Department of Defense Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center, San Diego, CA.

出版信息

Int Tinnitus J. 1998;4(2):141-143.

PMID:10753403

Abstract

In this study, we review the results of Menière's disease treatment using microdose gentamicin delivered directly to the round window using the Round Window Microcatheter (IntraEar, Inc., Denver, CO). A total of 18 patients were studied, with follow-up ranging from 6 to 18 months. In 15 of 18 patients (83%), tinnitus was improved significantly throughout the follow-up period. Vertigo was eliminated in all patients, and pressure was relieved in 17 of 18 (94%). Ihese preliminary data suggest that Round Window Microcatheter-delivered gentamicin is a safe and effective treatment for the reduction of tinnitus, vertigo, and pressure associated with Menière's disease.

摘要

在本研究中，我们回顾了使用圆窗微导管（IntraEar公司，科罗拉多州丹佛市）将微剂量庆大霉素直接输送至圆窗治疗梅尼埃病的结果。共研究了18例患者，随访时间为6至18个月。18例患者中有15例（83%）在整个随访期间耳鸣明显改善。所有患者眩晕均消除，18例中有17例（94%）压力得到缓解。这些初步数据表明，通过圆窗微导管输送庆大霉素是一种安全有效的治疗方法，可减轻与梅尼埃病相关的耳鸣、眩晕和压力。