Korobelnik J F, D'Hermies F, Chauvaud D, Legeais J M, Hoang-Xuan T, Renard G
Department of Ophthalmology, Fondation Opthalmologique Adolphe-de-Rothschild, Paris, France.
Ophthalmic Res. 2000 Mar-Jun;32(2-3):110-7. doi: 10.1159/000055599.
To investigate tissue changes induced by the implantation of expanded polytetrafluoroethylene (e-PTFE) used as encircling scleral buckling, an experimental and histopathological study was performed in rabbits. The eyes of 12 rabbits were implanted during 20-128 days with e-PTFE episcleral implants. Of these, 8 eyes were uncomplicated and enabled us to perform the histopathological study, 2 others were discarded for too short a time of implantation and, in 2 additional eyes, the episcleral implant was exposed with a wide conjunctival erosion. Surrounding the implant, a constant encapsulation was combined with numerous giant cells, forming a granuloma caused by irregularities of the implant outline. Its porous structure allowed a peripheral colonization by fibrovascular tissue. Scleral thinning and scleral invagination were the main scleral changes. No change of the conjunctiva made us suspect that a granuloma occurred before it was found histologically. The granulomatous changes did not seem to modify the apparently good experimental tolerance of the material after its implantation.
为研究用作环扎巩膜扣带术的膨体聚四氟乙烯（e-PTFE）植入后引起的组织变化，在兔身上进行了一项实验和组织病理学研究。12只兔的眼睛植入e-PTFE巩膜上植入物20至128天。其中，8只眼睛情况良好，可用于组织病理学研究，另外2只因植入时间过短而被舍弃，还有2只眼睛的巩膜上植入物暴露，伴有广泛的结膜糜烂。在植入物周围，持续形成包膜并伴有大量巨细胞，形成由植入物轮廓不规则引起的肉芽肿。其多孔结构允许纤维血管组织向周边生长。巩膜变薄和巩膜内陷是主要的巩膜变化。结膜无变化，这使我们怀疑在组织学发现肉芽肿之前就已发生。肉芽肿性变化似乎并未改变该材料植入后明显良好的实验耐受性。
