Karaküçük S, Mirza E, Sümerkan B, Okten T
Department of Ophthalmology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
Ophthalmic Res. 2000 Mar-Jun;32(2-3):126-31. doi: 10.1159/000055601.
This study was designed to test the effects of intravitreal trovafloxacin on an experimental rabbit model of Staphylococcus epidermidis endophthalmitis. Out of 26 rabbits, 22 were given intravitreal S. epidermidis (100,000 CFU). At 24 h, group 1 (8 rabbits) and, at 48 h, group 2 (8 rabbits) received 100 microg intravitreal trovafloxacin. Group 3 (6 rabbits) was used as inoculated but untreated controls. Four rabbits (group 4) were used as uninfected controls. Clinical scores were calculated at 24, 48 and 72 h. Microbiological and histopathological scorings were made. Microbiological analysis showed that trovafloxacin administered at 24 or 48 h significantly reduced the number of bacteria compared to the untreated group. We conclude that trovafloxacin applied at 24 or 48 h is effective against S. epidermidis endophthalmitis in this experimental rabbit model.
本研究旨在测试玻璃体内注射曲伐沙星对表皮葡萄球菌性眼内炎实验兔模型的影响。26只兔子中，22只接受玻璃体内注射表皮葡萄球菌（100,000 CFU）。24小时时，第1组（8只兔子），48小时时，第2组（8只兔子）接受100微克玻璃体内注射曲伐沙星。第3组（6只兔子）用作接种但未治疗的对照。4只兔子（第4组）用作未感染对照。在24、48和72小时计算临床评分。进行微生物学和组织病理学评分。微生物学分析表明，与未治疗组相比，在24或48小时给予曲伐沙星可显著减少细菌数量。我们得出结论，在24或48小时应用曲伐沙星对该实验兔模型中的表皮葡萄球菌性眼内炎有效。
