Ala-Fossi S L, Mäenpää J, Bläuer M, Tuohimaa P, Punnonen R
Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.
Eur J Endocrinol. 2000 Apr;142(4):334-9. doi: 10.1530/eje.0.1420334.
To compare serum and peritoneal fluid concentrations of inhibin A, B, and pro-alphaC in women with ovarian tumors.
Serum and peritoneal fluid samples were taken from 41 postmenopausal women operated on for an ovarian tumor. Twenty-one patients with endometrial cancer formed a control group. Serum and peritoneal fluid inhibin A, B, and pro-alphaC concentrations, and serum FSH and tumor marker CA 125 (study group only) concentrations were analyzed.
Inhibin A was found in low concentrations (median 4.1pg/ml, range <2-29pg/ml) in serum in most postmenopausal patients with epithelial ovarian carcinoma, whereas inhibin B was not measurable. Inhibin pro-alphaC circulated in high concentrations (median 125pg/ml, range 37->1000pg/ml). All inhibins were found in clearly greater concentrations in the peritoneal fluid than in serum. International Federation of Gynecology and Obstetrics (FIGO) stage III-IV and poor differentiation grade were associated with significantly lower concentrations of inhibin A and pro-alphaC in the peritoneal fluid compared with stages I-II or low grade. This correlation was not found in the serum concentrations of inhibin A or pro-alphaC. In the control group, no dimeric inhibins were found in serum, and pro-alphaC circulated in median concentrations of 47pg/ml (range 12-174pg/ml).
Postmenopausal patients with epithelial ovarian tumors had low concentrations of inhibin A and relatively high concentrations of inhibin pro-alphaC in serum. The peritoneal fluid concentrations of all inhibins far exceeded those in the serum. Relatively low concentrations of inhibin A and pro-alphaC in the peritoneal fluid of patients with ovarian cancer seem to be associated with high stage and grade and, to a lesser degree, with positive peritoneal cytology.
比较卵巢肿瘤患者血清和腹腔液中抑制素A、B及前αC的浓度。
采集41例因卵巢肿瘤接受手术的绝经后女性的血清和腹腔液样本。21例子宫内膜癌患者组成对照组。分析血清和腹腔液中抑制素A、B及前αC的浓度，以及血清卵泡刺激素（FSH）和肿瘤标志物CA 125（仅研究组）的浓度。
大多数绝经后上皮性卵巢癌患者血清中抑制素A浓度较低（中位数4.1pg/ml，范围<2 - 29pg/ml），而抑制素B无法检测到。抑制素前αC以高浓度循环（中位数125pg/ml，范围37 -> 1000pg/ml）。所有抑制素在腹腔液中的浓度明显高于血清。与国际妇产科联盟（FIGO）I - II期或低分化相比，III - IV期和低分化等级与腹腔液中抑制素A和前αC的浓度显著降低相关。在抑制素A或前αC的血清浓度中未发现这种相关性。在对照组中，血清中未发现二聚体抑制素，前αC的循环中位数浓度为47pg/ml（范围12 - 174pg/ml）。
绝经后上皮性卵巢肿瘤患者血清中抑制素A浓度低，抑制素前αC浓度相对较高。所有抑制素在腹腔液中的浓度远超过血清中的浓度。卵巢癌患者腹腔液中抑制素A和前αC浓度相对较低似乎与高分期和高分级相关，且在较小程度上与腹腔细胞学阳性有关。
