Lambert-Messerlian G M, Steinhoff M, Zheng W, Canick J A, Gajewski W H, Seifer D B, Schneyer A L
Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Providence, Rhode Island 02905, USA.
Gynecol Oncol. 1997 Jun;65(3):512-6. doi: 10.1006/gyno.1997.4719.
Inhibin is an ovarian protein previously shown, using a nonspecific assay, to be elevated in serum of women with ovarian cancer. However, inhibin is secreted in multiple biochemical forms, including dimeric inhibin A and B and alpha inhibin precursors (pro-alphaC), each of which can now be specifically measured. We have examined the secretion of inhibin B and pro-alphaC inhibin in serum from women with epithelial ovarian cancer (EOC) for the first time, and have compared these analytes to inhibin A and total inhibin (inhibin A + B + pro-alphaC) as potential serum markers for EOC in postmenopausal women. Of all the immunoreactive inhibin proteins studied, the best serum marker was pro-alphaC, with 22% of women with EOC having levels that exceeded the range of values in women without EOC. Since CA 125 and pro-alphaC levels were not significantly correlated, combination of these markers resulted in 87% of EOC cases having elevated preoperative serum levels, a 9% increase over CA 125 alone. These data suggest that alpha inhibin secretion, especially pro-alphaC, may be useful in addition to CA 125 as a serum marker for EOC in postmenopausal women.
抑制素是一种卵巢蛋白，此前使用非特异性检测方法显示，卵巢癌女性血清中的抑制素水平会升高。然而，抑制素以多种生化形式分泌，包括二聚体抑制素A和B以及α抑制素前体（pro-αC），现在每种形式都可以进行特异性检测。我们首次检测了上皮性卵巢癌（EOC）女性血清中抑制素B和pro-αC抑制素的分泌情况，并将这些分析物与抑制素A和总抑制素（抑制素A+B+pro-αC）进行比较，作为绝经后女性EOC的潜在血清标志物。在所有研究的免疫反应性抑制素蛋白中，最佳血清标志物是pro-αC，22%的EOC女性其水平超过了无EOC女性的数值范围。由于CA 125和pro-αC水平无显著相关性，联合使用这些标志物使87%的EOC病例术前血清水平升高，比单独使用CA 125增加了9%。这些数据表明，除CA 125外，α抑制素分泌，尤其是pro-αC，可能作为绝经后女性EOC的血清标志物具有一定作用。
