Ninfa A J, Atkinson M R
Dept of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109-0606, USA.
Trends Microbiol. 2000 Apr;8(4):172-9. doi: 10.1016/s0966-842x(00)01709-1.
PII proteins, found in Bacteria, Archaea and plants, help coordinate carbon and nitrogen assimilation by regulating the activity of signal transduction enzymes in response to diverse signals. Recent studies of bacterial PII proteins have revealed a solution to the signal transduction problem of how to coordinate multiple receptors in response to diverse stimuli yet permit selective control of these receptors under various conditions and allow adaptation of the system as a whole to long-term stimulation.
PII蛋白存在于细菌、古菌和植物中，通过响应各种信号调节信号转导酶的活性，帮助协调碳和氮的同化作用。最近对细菌PII蛋白的研究揭示了信号转导问题的一个解决方案，即如何协调多个受体以响应各种刺激，同时在不同条件下允许对这些受体进行选择性控制，并使整个系统适应长期刺激。
